The aim of the project "Parametric spatial design" was the development of an intensive care unit that supports the healing process of the patients. Our research included aspects such as room acoustics (reducing noise of alarms and signals) as well as temperature control and all visual aspects of stress-reducing factors (such as materials, light, color and media surfaces). The central component of our interior concept was a purpose-built interface: The surface is controlled by physicians and health care professionals as well as the patient, who can also personalize the content. In addition to that, the interface is adjusted automatically taking into account environmental para­meters and vital signs of the patient. The design of the interactive intensive care room also assures the disappearance of medical equipment and all related components within a modular wall system situated in the patient's back and head region while maintaining readability of the measured data and easy access to all devices. Also the acoustic stress is reduced significantly and the climatic conditions are improved. The performance of interactive parametric spatial design is verified through the systematic evaluation of all the relevant indicators. The project "Parametric spatial design" was developed in collaboration with Charité, Charité CFM Facility Management and Art + Com.